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Cyclerion Therapeutics Praliciguat Fails in Two Crucial Clinical Trials

Cyclerion Therapeutics (NASDAQ: CYCN), a clinical-stage Company, announced the failure of its drug candidate praliciguat in meeting the primary endpoints in two separate clinical studies, in diabetic nephropathy (DN) and heart failure with preserved ejection fraction (HFpEF). Praliciguat is a soluble guanylate cyclase (sGC) stimulator...

Otonomy Enters Strategic Collaboration with AGTC to develop a novel Gene Therapy for Congenital Hearing Loss

Otonomy Inc (NASDAQ: OTIC), a biopharmaceutical company focussed on providing neurotology solutions, announced a strategic collaboration with Applied Genetic Technologies Corporation (NASDAQ: AGTC), a biotechnology company developing adeno-associated virus (AAV)-based gene therapies for the treatment of rare diseases, to create, develop and commercialize an AAV-based...

Top 5 Emerging Therapeutics for Crigler – Najjar Syndrome

Crigler Najjar Syndrome, also called hyperbilirubinemia, is a chronic condition characterized by high levels of unconjugated bilirubin in the blood. The disease manifests as Jaundice at birth, and can progressively lead to kernicterus, a condition in which the accumulation of unconjugated bilirubin can damage brain...

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